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研究领域：     

        实验室研究方向：水稻氮磷营养利用效率和种子休眠萌发的表观遗传调控机制

        课题组使用前沿生物技术手段，解决农业生产中的两个重大问题，即化肥利用效率低和穗发芽。旨在服务于精准农业，推进绿色高效优质农业的发展。

        现代农业生产高度依赖氮磷等化肥的大量施用，而化肥的大量施用又影响着稻米品质、水体及大气污染。因此，化肥过量使用已成为农业生产亟需解决的关键问题之一。

        穗发芽(Pre-harvest srouting, PHS) 是指作物在收获前，种子在穗上过早萌发的现象。穗发芽导致淀粉和蛋白降解，严重影响产量和品质，是一个亟待解决的农业问题。 

        课题组围绕化肥利用率低和穗发芽这两个重要的农业问题，将主要使用表观遗传学和相分离的技术手段，结合分子生物学、生物化学、遗传学、细胞生物学、生物信息学等学科，研究如下内容：

1. 表观遗传学和相分离机制如何调控水稻氮磷营养利用效率

            将探索植物的表观组如何响应于营养信号，以及营养信号转导通路如何受表观遗传机制的调控。关注的表观机制包括DNA甲基化、组蛋白修饰、组蛋白变异体和染色质高级结构。

            另外，将探索相分离(Phase separation)与营养信号的相互调控机制。

2. 表观遗传学和相分离机制如何调控水稻种子休眠萌发

            将探索在水稻种子休眠和萌发过程中，表观遗传机制和蛋白的相分离是否以及如何变化（或称为重编程），及这些变化的分子机制和生物学意义。

教育经历：

        2002年 - 2006年  河南大学 学士学位

        2006年 - 2009年  上海交通大学生命科学技术学院 硕士学位 

        2009年 - 2015年  上海交通大学农业与生物学院 博士学位

工作经历：

        2015年 - 2021年  英国John Innes Centre  博士后

        2021年 -               澳门十大正规娱乐平台APP  首聘教授

论文著作：

1. Toby Buttress^#, Shengbo He^#, Liang Wang^#, Shaoli Zhou^#, Gerhard Saalbach, Martin Vickers, Guohong Li, Pilong Li*, Xiaoqi Feng*. 2022. A histone variant condenses flowering plant sperm via chromatin phase separation. Nature (^#Equal contributions)

2. Jingyi Zhang and Shengbo He*. 2021. Tobacco System for Studying Protein Colocalization and Interactions. Methods in Molecular Biology 2297:167-174. (*Corresponding) 

3. Jingyi Zhang and Shengbo He*. 2021. Co-immunoprecipitation Assay for Blue Light-Dependent Protein Interactions in Plants. Methods in Molecular Biology 2297:141-146. (*Corresponding)

4. Pingtao Ding*, Toshiyuki Sakai, Ram Krishna Shrestha, Nicolas Manosalva Perez, Wenbin Guo, Bruno Pok Man Ngou, Shengbo He, Chang Liu, Xiaoqi Feng, Runxuan Zhang, Klaas Vandepoele, Dan MacLean, Jonathan DG Jones*. 2021. Chromatin accessibility landscapes activated by cell surface and intracellular immune receptors. Journal of Experimental Biology erab373. 

5. Zhilei Mao#, Shengbo He#, Feng Xu#, Wenxiu Wang, Ting Li, Pengbo Xu, Shasha Du, Ling Li, Hongli Lian, and Hong-Quan Yang. 2020. CRY1 and phyB interact directly with ARF6 and ARF8 to regulate auxin-responsive gene expression and hypocotyl elongation in Arabidopsis. New Phytologist 225(2):848-865. (#Equal contributions) 

6. Shengbo He, Martin Vickers, Jingyi Zhang, and Xiaoqi Feng. 2019. Natural Depletion of h2 in Sex Cells Causes DNA Demethylation, Heterochromatin Decondensation and Transposon Activation. eLife 8 e42530. 

7. Feng Xu#, Shengbo He#, Jingyi Zhang, Zhilei Mao, Wenxiu Wang, Ting Li, Jie Hua, Shasha Du, Pengbo Xu, Ling Li, Hongli Lian, and Hong-Quan Yang. 2018. Photoactivated CRY1 and phyB Interact Directly with AUX/IAA Proteins to Inhibit Auxin Signaling in Arabidopsis. Molecular Plant 11(4):523-541. (#Equal contributions) 

8. Hongli Lian*, Pengbo Xu*, Shengbo He, Jun Wu, Jian Pan, Wenxiu Wang, Feng Xu, Sheng Wang, Junsong Pan, Jirong Huang, and Hong-Quan Yang. 2018. Photoexcited CRYPTOCHROME 1 Interacts Directly with G-Protein β Subunit AGB1 to Regulate the DNA-Binding Activity of HY5 and Photomorphogenesis in Arabidopsis. Molecular Plant 11(10):1248-1263. (*Equal contributions) 

9. Ping-Hung Hsieh#, Shengbo He#, Toby Buttress, Hongbo Gao, Matthew Couchman, Robert L. Fischer, Daniel Zilberman, and Xiaoqi Feng. 2016. Arabidopsis male sexual lineage exhibits more robust maintenance of CG methylation than somatic tissues. Proc. Natl. Acad. Sci. USA 113(52):15132-15137. (#Equal contributions) 

10. Sheng-Bo He, Wen-Xiu Wang, Jing-Yi Zhang, Feng Xu, Hong-Li Lian, Ling Li and Hong-Quan Yang. 2015. The CNT1 Domain of Arabidopsis CRY1 Alone Is Sufficient to Mediate Blue-Light Inhibition of Hypocotyl Elongation. Molecular Plant 8(5):822-825. 

11. Jing-Yi Zhang, Sheng-Bo He, Ling Li, and Hong-Quan Yang. 2014. Auxin Inhibits Stomatal Development through MONOPTEROS Repression of A Mobile Peptide Gene STOMAGEN in Mesophyll. Proc. Natl. Acad. Sci. USA 111(29):E3015-3023. 

12. Qian Luo, Hong-Li Lian, Sheng-Bo He, Ling Li, Kun-Peng Jia, and Hong-Quan Yang. 2014. COP1 and PhyB Physically Interact with PIL1 to Regulate Its Stability and Photomorphogenic Development in Arabidopsis. Plant Cell 26(6):2441-2456 

13. Kun-Peng Jia, Qian Luo, Sheng-Bo He, Xue-Dan Lu and Hong-Quan Yang. 2014. Strigolactone-Regulated Hypocotyl Elongation Is Dependent on Cryptochrome and Phytochrome Signaling Pathways in Arabidopsis. Molecular Plant 7(3):528-40.

14. Hong-Li Lian, Sheng-Bo He, Yan-Chun Zhang, Dan-Meng Zhu, Jing-Yi Zhang, Kun-Peng Jia, Shu-Xia Sun, Ling Li, and Hong-Quan Yang. 2011. Blue-Light-Dependent Interaction of Cryptochrome 1 with SPA1 Defines A Dynamic Signaling Mechanism. Genes & Development 25(10):1023-8. 

15. Xin Li, Sheng-Bo He, Li-Li Zhuang, Shusei Sato, Satoshi Tabata, Mike Ambrose, Catherine Rameau, Jun Yang, Xiao-He Hu, and Da Luo. 2010. Genetic Analysis and Comparative Mapping of BIO and ELE2 Loci in Lotus japonicus and Pea. Genomics and Applied Biology 29(1):3-9.

16. Sheng-Bo He#, Wei He#, Hong-Qi Chen, Xu-Dong Zhu, Jun Yang, Xiao-He Hu, and Da Luo. 2009. Characterization and Mapping of Rice Mutants, des2 and des5. Genomics and Applied Biology 28(1):1-9. (#Equal contributions)